摘要
目的观察硝苯地平缓释片(纳欣同)联合依那普利治疗老年人原发性高血压的临床疗效。方法将老年原发性高血压患者180例随机分为A、B、C组各60例。A组予纳欣同口服,每次20mg,每天1～2次;B组予依那普利片口服,每次10mg,每天2次;C组予纳欣同联合依那普利治疗,纳欣同用法用量同A组,依那普利片用法用量同B组。治疗后比较3组临床疗效及不良反应。结果 C组总有效率为96.7%高于A组的66.7%和B组的60.0%,差异均有统计学意义(P<0.01)。C组与A组不良反应发生率比较差异无统计学意义(P>0.05)。但各组患者均可耐受,不影响治疗。结论纳欣同联合依那普利治疗老年人原发性高血压疗效显著,且不良反应轻微,值得推广应用。
Objective To observe the clinical effect of nifedipine sustained release tablet（naxintong） combined with enalapril in elderly patient with essential hypertension. Methods 180 cases elderly patients with essential hypertension were randomly divided into A, B, C group, each of 60 cases. A group were given naxintong oral, each time 20mg, 1 or 2 times a day ; B group received enalapril oral, each time 10mg,twice a day;C group were given naxintong combined with enalapril treatment. After treatment,compared clinical efficacy and adverse reaction of three groups. Results The total effective rate of C group （96.7%） was higher than that of A group（ 66. 7% ） and B group（60.0% ） ,the difference were statistically significant（P 〈 O. 01 ）. The incidence of adverse reaction in C group and A group were no significant difference（P 〈0.05）. However,patients in each group cound be tolerated, did not affect the treatment. Conclusion Naxintong combined with enalapril in elderly patient with essential hypertension is effective, and adverse reaction mild, should be widely applied.
出处
《临床合理用药杂志》
2012年第19期10-11,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
硝苯地平缓释片
依那普利
高血压
原发性
老年人
Nifedipine sustained release tablet
Enalapril
Hypertension, essential
Elderly
