摘要
目的观察碘普罗胺冠状动脉造影对患者肾脏功能的影响,为临床工作提供参考。方法选择我院2008年3月~2012年2月收治的行碘普罗胺冠状动脉造影患者3 953例,回顾性分析其临床资料,观察造影前后患者肾功能各指标的变化和焦虑程度的改善情况。结果全部患者中422例患者造影后发生肾功能异常,肾功能异常发生率为10.68%。发生肾功能异常患者造影后24、48 h血清尿素氮（BUN）、肌酐（SCr）水平明显升高,与造影前比较,差异有统计学意义（P〈0.05）。肾功能异常患者中388例于造影72 h后恢复正常,恢复率为91.94%。造影后患者的焦虑程度明显改善,与造影前比较,差异有统计学意义（P〈0.05）。结论采用碘普罗胺作为冠状动脉造影剂对患者肾脏功能影响较小,其肾损害多为一过性,临床应用较为安全。
Objective To observe the effect of Iopromide coronary artery angiography on renal function of patients, in order to provide reference for clinical work. Methods 3 953 patients underwent Iopromide coronary artery angiography in our hospital from March 2008 to February 2012 were selected, and the clinical data were analyzed retrospectively. Renal func- tion changes in various indices and the improvement condition of anxiety degree before and after angiography were ob- served. Results 422 cases of patients suffered with abnormal renal function after angiography, the occurrence rate was 10.68%. Compared with before angiography, the serum urea nitrogen （BUN）, creatinine （SCr） levels of patients with abnor- mal renal function at 24, 48 h after angiography significantly increased, the differences were statistically significant （P 〈 0.05）. Among all abnormal renal function patients, 388 patients were convalescent within 72 h after angiography, the recov- ery rate was 91.94%. After treatment the anxiety level of patients was significantly improved than that of before treatment, the difference was statistically significant （P 〈 0.05）. Conclusion Taking Iopromide as coronary artery contrast agents has less effect on renal function of patients, it is a transient damage for kidney and safety for clinical application.
出处
《中国医药导报》
CAS
2012年第18期48-49,共2页
China Medical Herald
