摘要
目的 :对中晚期食管癌单纯放疗与放疗加PVB方案化疗的疗效观察。方法 :1990— 1992期间在诊科诊治的中晚期食管癌 110例随机分为单放组与化—放疗组两组 ,两组均给以 6 5— 70Gy/ 6— 8周的常规放疗 ,化—放组是在放疗时同步加PVB方案化疗 (cisplaqtin 2 0mg/m2 ,ivgtt,d1— 5 ;vincristinum 1.4mg/m2 ,iv ,d1;pingyangmycinum15mg/m2 ,iv,d2、8、15 )两个疗程。结果 :近期疗效单放组总有效率为 6 7 2 7%。化—放组为 85 45 % ,两组比较有显著性差异 (P <0 0 5 ) ;一、三、五年存活率单放组为 43 6 4% ,16 36 % ,10 91% ,而化放组为 6 7 2 7%、38 18%、2 5 45 % ,化—放组的一、三、五年存活率均高于单放组 (P <0 0 5 ) ;化疗组的毒副反应为胃肠道反应及一过性白细胞下降 ,均能耐受 ,两组肺的急、慢性放射反应损伤相同。结论
Purpose:To evaluate the effect of PVB chemotherapy plus radiation for advanced esophageal cancer. Methods:From April 1990 to December 1992, 100 patients with advanced esophageal cancer were randomized into two groups: radiotherapy(RT) group——55 patients received RT alone;chemoradiotherapy (CRT) group ——55 patients receieved RT combined with chemotherapy with cisplatin: 20 mg/m 2. iv.gtt.d1—5; vincristinum 1.4 mg/m 2. iv. da; pingyangmycinum 15 mg/m 2.iv.d2、8、15 for 2 cycles during radiotherapy. Rt in both groups was similar (65—70 Gy/6—8 W with routine fractionation). Results:The response was 67.27% in RT group and 85.45% in CRT group, The difference in response was statistically significant ( P <0 05); The 1、3、5 year survived rates were 43.64%, 16.36%,10.91% respectively in RT group and 67.27%, 38.18% 25.45% respectively in CRT group. The survival rates in CRT group were all higher than that in RT group( P <0 05); The major toxicity of chemotherapy (gastrointerstinal nausea, vomting and myelosuppression leukopenia)were all acceptable;Radiation toxicity inboth groups (actue and late lung injury) was similar. Conclusions:The result shows that CRT for advanced esophageal cancer is acceptable and the total effect superior to RT alone.
出处
《中国癌症杂志》
CAS
CSCD
2000年第2期132-133,共2页
China Oncology
