摘要
目的 :观察硫普罗宁 (Tiopronin ,MPG)对化疗所致小鼠白细胞减少的预防和治疗作用。方法 :采用环磷酰胺 (CPA)造成小鼠外周血白细胞减少的动物模型 ,观察MPG对由化疗所致白细胞减少的防治作用。结果 :预先用不同剂量MPG给小鼠经口灌胃或腹腔注射 (ig或ip) ,用药 5d ,再腹腔注射 1次CPA ,然后于第 3d计数白细胞总数 ,同时与单用CPA相比差异具有显著性 (P <0 .0 5或P <0 .0 1)。先腹腔注射CPA ,再用不同剂量MPG对小鼠经口灌胃或腹腔注射进行治疗 ,然后于第 3d、第 5d计数白细胞总数 ,与单用CPA组相比差异具有显著性 (P <0 .0 5或P <0 .0 1)。结论 :MPG具有明显的预防和治疗CPA所致的小鼠白细胞减少的作用。
Aim:To observe the effect of tiopronin(MPG)in the prevention and treatment of leukocytopenia induced by chemotherapy in mice.Methods:We adopted cyclophosphamide(CPA)to make the model of peripheral blood cell reducing in mice,and observed that MPG prevented and treated the leukopenia caused by chemotherapy.Results:After mice were administered 250 mg·Kg -1 and 500 mg·Kg -1 of MPG once daily for 5 days by intragastic(ig),or 150 mg·Kg -1 and 300 mg·Kg -1 of MPG once daily for 5 days by intraperitoneal(ip),and CPA was intraperitoneal injected once time,then counted the total white blood cells(WBC).Compared with the model control group,the different doses group of treated by MPG was very notable( P <0.05 or P <0.01).If CPA was used to mice at first,and the different doses of MPG were given by ig or ip,then counted WBC at the 3th day and 5th day.Compared with the model control group,the difference between MPG and CPA groups were significant( P <0.05 or P <0.01). Conclusion:The results suggest that the MPG had obvious action of prevention and treatment on leukopenia induced by CPA in mice.
出处
《河南医科大学学报》
2000年第3期241-243,共3页
Journal of Henan Medical University
基金
国家"八五"攻关资助课题!85 92 2 0 2 7
