摘要
目的:探讨血管紧张素II受体拮抗剂(ARB)坎地沙坦对自发性高血压大鼠(SHR)炎性因子水平及胰岛素抵抗的影响。方法:30只SHR随机分为模型组、坎地沙坦高剂量组及低剂量组,10只WKY大鼠作为对照组,4组大鼠均给与果糖喂养,高、低剂量组同时给与对应剂量的坎地沙坦灌胃干预,8周后观察各组大鼠血压、胰岛素抵抗指数和炎性因子IL-2、IL-6、CRP的水平。结果:模型组大鼠血压、胰岛素抵抗指数及血清IL-6、CRP均较对照组升高,差异有统计学意义(P<0.01);坎地沙坦干预的大鼠与模型组大鼠相比,以上指标则明显降低,差异有统计学意义(P<0.05)。结论:坎地沙坦可能通过降低炎性因子IL-6、CRP的水平来改善胰岛素抵抗。
Objective： To investigate the effects of candesartan on inflammatory cytokines and insulin resistance in spontaneously hypertensive rats （SHR）. Methods： Thirty SHR were randomly divided into model group （ group M）, high dose of candesartan group （ group H） and low dose of candesartan group （ group L）. Ten WKY rats served as control group. All rats were fed with fructose, while the rats in groups L and H were given corresponding doses of candesartan by garage. After 8 weeks, blood pressure, insulin resistance index and serum levels of inflammatory cytokines including IL-2, IL-6 and C-reactive protein （CRP） of rats in the 4 groups were detected. Results： The blood pressure, insulin resistance index and serum levels of IL-6 and CRP in group M were significantly higher than those of control （P 〈 0. 01 ）. With the treatment of candesartan, the indicators mentioned above were decreased significantly in groups L and H （P 〈 0. 05 ）. Conclusions： Candesartan may improve insulin resistance by reducing the serum inflammatory cytokines IL-6 and CRP levels.
出处
《贵阳医学院学报》
CAS
2012年第3期263-266,共4页
Journal of Guiyang Medical College
基金
北京市自然科学基金资助项目(7122171)
