摘要
背景:通过胰腺或胰岛移植等重建胰岛素分泌系统是治疗1型糖尿病的有效方法,但材料来源受限,移植后免疫排斥反应易导致治疗失败。目的:简要总结了胚胎干细胞、成体干细胞及诱导性多能干细胞等治疗1型糖尿病的研究进展。方法:应用计算机检索CNKI和PubMed数据库中2008-01/2011-12关于干细胞治疗1型糖尿病的文章,在标题和摘要中以"胚胎干细胞;成体干细胞;诱导性多能干细胞;1型糖尿病"或"Embryonic stem cells,somatic stem cells,induced plurip otent stem cells,type 1 diabetes"为检索词进行检索。选择文章内容与干细胞治疗1型糖尿病相关,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到128篇文献,根据纳入标准选择33篇文章进行综述。结果与结论:目前,不同来源的干细胞在体内外均能被诱导为产生胰岛素的细胞,并且这种诱导细胞用于1型糖尿病动物模型治疗,具有一定治疗效果,甚至能使受体血糖恢复正常水平,但干细胞是否参与胰岛细胞再生或修复尚存在争议。
BACKGROUND： The possible effective way for the treatment of type 1 diabetes mellitus is to rebuild the secreting system of insulin through pancreatic or pancreatic islet transplantation. However, limited donors and rejection after transplantation often lead to failed treatment. OBJECTIVE： To summarize the study progress in embryonic stem cells, somatic stem cells and induced pluripotent stem cells for the treatment of type 1 diabetes mellitus. METHODS： Articles addressing stem cells for the treatment of type 1 diabetes mellitus were retrieved online in CNKI database and PubMed database from January 2008 to December 2011 with the key words of ＂embryonic stem cells, somatic stem cells, induced pluripotent stem cells, type 1 diabetes mellitus＂ in Chinese and English in the title and abstract. The articles related to stem cells for the treatment of type 1 diabetes were included. For the articles in the same field, those published recently or in the authorize journals were preferred. A total of 128 literatures were obtained, and 33 documents of them were involved for review according to the inclusion criteria. RESULTS AND CONCLUSION： Recently, different sources of stem cells could be induced into insulin-producing cells in vivo or in vitro, and the induced cells were used in the treatment of animal model with type 1 diabetes. It showed certaub therapeutic efficacy and even made recipient＇s blood sugar level returned to normal. But controversy exists regarding whether stem cells took part in islet cell regeneration or repair.
出处
《中国组织工程研究》
CAS
CSCD
2012年第23期4349-4353,共5页
Chinese Journal of Tissue Engineering Research
