摘要
在不同肾功能状态的病人中 ,观察静脉推注单剂量头孢地秦 16 .2 mg/ kg的药代动力学。结果表明 ,肾功能变化对其药代动力学参数有显著影响 ,药物经肾清除率和清除半衰期与肌酐清除率密切相关 ,在肾功能严重受损的病人中 ,感染时用药方案需调整 ,根据药代动力学的变化减少为正常剂量的 1/ 3,或用药间隔延长 3倍。
The pharmacokinetics of cefodizime was investigated in patients with different degree of renal dysfunction. A single dose of 16.2mg/kg of cefodizime was injected in vein. Serum and urine samples were collected at different intervals for investigation of the drug concentration with bioassay and high performance liquid chromatography. Pharmacokinetic parameters were analyzed by assuming an open two compartment model. Apparent difference was observed in pharmacokinetic parameters between patients with impaired renal function and those with normal renal function. For the former group, the area under the curve of serum concentration versus time was tripled: 896.24±115.7 and 349.61±11.88h·mg/L; the renal clearance of cefodizime was reduced: 7.62±2.43 and 37.3±1.29ml/min; and the elimination half life was prolonged: 8.13±1.67 and 2.41±0.21h respectively. On the basis of these findings, it is suggested that a reduction of 2/3 of the dose of cefodizime an increase of three times of the administration time intervlas may be indicated in chronic renal failure with GFR less than 10.67ml/min.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2000年第2期117-119,共3页
Chinese Journal of Antibiotics
