摘要
统计了四川省人民医院1991年～1995年抗菌药物使用数量、金额,采用WHO推荐的“限定日剂量(DDD)”作为药物研究的剂量单位,确定DDD值,计算DDD数(日用药人次,DDDs),将总购入量、DDD数及金额进行排序,求出金额序号与DDDs序号比值,从中了解全院抗菌药物用药频度及购药金额与用药人次是否同步。将用药频度大的几种抗菌药物和几种头孢类抗生素作药敏试验,以了解其耐药程度。结果表明:历年本院使用的第三代头孢类抗生素所占金额比重极大。在DDDs排序中居前10位的有青霉素类、喹诺酮类、氨基甙类、大环内酯类,但头孢类抗生素极少进入前十位,喹诺酮类用药频度逐年提高。细菌对几种用药频度大的抗菌药物有50％以上产生了耐药性,而对几种头孢类抗生素还较敏感。
This study analyzed the amount and expenditure of antibiotics used in our hospital from 1991 to 1995 in order to find the relationship between the frequency of antibiotics use and definite daily dosage. The total amount, DDD number and expenditure of each antibiotics were listed in order. The ratio of order number of expenditure to order number of DDDs was calulated. Several most frequently used antibiotics were selected for drug sensitivity test to investigate drug resistance of germs to these drugs. Our results showed that 1) the third generation cephalosporins accounted for a large proportion of procurement expenditure; 2) the top ten antibiotics in the DDDs list were benzylpenicillins, quinolornes, aminoglysider and maxrolides etc. . However, only few cephalosporins were listed in the top ten antibiotics in terms of DDDs; 3) the frequency of quinolomes used in our hospital was raising year by year; 4) resistance has been found im more than 50% of those frequently used antibiotics. On the other hand, bacteria are more sensitive to cephalosporins than other antibiotics.
出处
《药物流行病学杂志》
CAS
1997年第2期96-100,共5页
Chinese Journal of Pharmacoepidemiology
