摘要
目的建立胸部爆炸伤模型 ,深入研究胸部爆炸伤的致伤机制、急性肺损伤的发病机制。方法采用破片发射复合冲击波并结扎肋间动脉方法建立模型 ,观察伤后生理参数、血气分析、病理及肺表面活性物质变化。结果建立的动物模型较好模拟现场爆炸效果 ,模型可靠 ,结果重复性好 ,失血性休克和急性呼吸功能衰竭是死亡的主要原因。结论该模型可用于胸部爆炸伤的实验室研究。
Objective To establish the model of thoracic explosive injury for studying its mechanism and acute lung injury. Methods Emission of fragments in combination blast and ligation of arteriae intercostales were used to establish the model in rabbits. Then the changes of physiological parameters, blood gas, pathology and pulmonary surfactant were observed. Results The model could well imitate the thoracic explosive injury on the ground testing and was convincible and could be repeated well. Bleeding shock and acute respiratory derangement were found to be the major causes for early death. Conclusion The model can be used in future studies on thoracic explosive injury.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2000年第4期328-330,共3页
Journal of Third Military Medical University
基金
全军"九五"指令性课题!(96L039)
关键词
动物模型
肺表面活性物质
胸部爆炸伤
s:thoracic trauma
explosive injury
animal model
pulmonary surfactant
