摘要
目的 探讨大剂量抑肽酶对兔胸部撞击伤致肺挫伤的治疗作用及其可能机制。方法 采用兔单侧肺挫伤生物撞击模型 ,动态观察抑肽酶对其动脉血氧分压、血浆和支气管肺泡灌洗液 (brochoalveolarlavagefluid ,BALF)中肿瘤坏死因子 α(TNF α)和弹性蛋白酶 (NE)含量变化的影响。进行肺组织的病理学光镜检查对比。结果 抑肽酶治疗组与创伤模型组相比较 ,血浆和BALF中TNF α和NE含量均明显降低 (P <0 .0 1或P <0 .0 5 ) ,肺组织损伤程度减轻。结论 肺挫伤早期应用抑肽酶能够抑制TNF α的产生 ,使肺泡白细胞浸润程度减轻 ,NE释放减少 。
Objective To investigate the experimental effects of large dose of aprotinin on pulmonary contusion after chest impact trauma in rabbits.?Methods Isolated lung contusion model of the rabbit was extablished by subjecting the animals to chest impact trauma using a bioimpact machine.?Rabbit models were used to monitor the effect of aprotinin on arterial oxygen pressure,and changes in tumor necrosis factor A(TNF α)and elastase(NE)contents both in plasm and bronchalvelor lavage fluid(BALF)(P<0.01 or P<0.05).?The histological features of lung were examined by naked eyes and light microscope.?Results Compared with the injured group,large dose of aprotinin treatment could significantly improve the arterial oxygen partial pressure,decrease the TNF α level and elastase contents in plasma and BALF.?Pathological examination revealed a marked improvement in lung tissue with decreased wet/dry weight of lung.?Conclusion Large dose of aprotinin treatment could attenuate trauma induced lung contusion in rabbits.
出处
《创伤外科杂志》
2004年第4期289-291,共3页
Journal of Traumatic Surgery
