摘要
目的:观察黄芪注射液治疗糖尿病肾病的疗效。方法:收集糖尿病患者24h尿液,均经防腐处理,准确记录尿量,留取6ml,冷藏备用,以测定尿微量白蛋白(Alb)和肌酐(Cr)尿β2微球蛋白(尿β2M)。按24h尿排泄率(uAE)将受试者分成3组:大量白蛋白尿组(uAE>300mg/24h)微量白蛋白尿组(μAE30～300mg/24h)和正常白蛋白尿组(uAE<30mg/24h)。每组又随机分成治疗组和对照组,两组的年龄、病程、病情大致相近。其中对照组维持原方案治疗,观察4周;治疗组在原治疗方案的基础上加用黄芪注射液,剂量40～60ml/d,静点,2～4周为一疗程。结果:治疗组在3周后uAE明显下降(P<0.01)。结论:黄芪注射液能降低肾脏蛋白的排泄,治疗糖尿病肾病有一定疗效。
Objective: To investigate the efficacy of Astragalus Injection on diabetic nephrosis.Method: Collecting the diabetic patients' 24 hour urina and treating it to prevent from rot, recording the urinary amount exactly, setting apart 6ml and refrigerating it for use in order to detect urinary microalbumin (Alb), creatinine (Cr) and urinary β2 microglobulin (urinary β2 M). According to the urinary excretory rate of 24h, patients were divided into three groups: the macroalbumin urinary group (UAE>300 mg/24 hours), microalbumin urinary group (UAE 30 300 mg/24 hours), and normal albumin urinary group (UAE<30 mg/24 hours). Every group was divided into therapy and control group randomly. The age, disease course and condition of two groups were mostly similar. The control group was treated according to the original plan and was observed for four weeks. The therapy group was treated with the method based on the original treatment plan adding Astrgalus Injection, 40 60 ml/d, intravenous drip, 2 4 weeks constituting a single therapentic course. Rensults: The uEA of the therapy group could decrease significantly after three weeks ( P <0.01). Conclusion: Astragalus Injection can decrease the excretion of protein in kindey and is effective for diabetic rephrosis.
出处
《中成药》
CAS
CSCD
2000年第3期207-209,共3页
Chinese Traditional Patent Medicine
