摘要
目的探讨采用机体内环境稳定方法治疗高热及超高热患儿的临床意义。方法将216例高热及超高热患儿按随机原则分为治疗组（109例，采用内环境稳定治疗）和对照组（107例，给予常规退热、抗感染），观察治疗后患儿平均退热时间、3d白细胞计数（WBC）和超敏C-反应蛋白（hs—CRP）及住院时间；同时观察病程中肝功能损害、高血糖、低血钾、心肌损伤、心力衰竭、代谢性酸中毒等并发症的发生率及临床疗效。结果与对照组比较，治疗组退热时间（d：3．26±0．38比3．86±0．41）、住院时间（d：9．26±1．31比12．31±1．78）明显缩短（均P〈0．01）；3dWBC（×10^9／L：7．56±1．58比9．58±2．21）和hs—CRP（mg／L：6．35±2．14比13．80±3．09）均明显降低（均P〈0．01）。治疗组肝功能损害、高血糖、低血钾、代谢性酸中毒的发生率均明显低于对照组（肝功能损害：23．85％比36．45％，高血糖：23．85％比39．25％，低血钾：4．59％比19．63％，代谢性酸中毒：17．43％比35．51％，P〈0．05或P〈0．01）；心肌损伤、心力衰竭发生率低于对照组（心肌损伤：15．60％比24．30％，心力衰竭：6．42％比10．28％），但比较差异无统计学意义（均P〉O．05）；治疗组治愈率高于对照组（88．07％比72．90％，P〈0．01）。结论对高热及超高热患儿采用稳定内环境治疗能明显减少机体内环境紊乱和并发症的发生率，缩短病程，提高疗效，是一种经济、有效的治疗手段，值得临床推广。
Objective To approach the clinical significance of using homeostasis method for treatment of children with high fever and super high fever. Methods Two hundred and sixteen cases of children with high fever and super high fever were randomly divided into treatment group （ 109 cases, treated by internal environment stabilization） and control group （ 107 cases, treated by general antipyretic and anti-infection）. The average time of abatement of fever after treatment, 3-day white blood cell count （WBC） and high sensitivity C-reactive protein （hs-CRP）, and the length of stay in hospital were explored ; at the same time the incidences of liver function damage, high blood sugar, low blood potassium, metabolic acidosis, myocardial injury, heart failure, and other complications and clinical efficacy were observed. Results The average time for abatement of fever （days ： 3.26＋0.38 vs. 3.86＋0.41） and the length of stay in hospital （days ： 9.26±1.31 vs. 12.31±1.78） in treatment group were significantly reduced as compared with those in control group （both P〈0.01） ; 3-day WBC （ ×109/L ： 7.56＋1.58 vs. 9.58±2.21） and hs-CRP （mg/L ： 6.35 ±2.14 vs. 13.80±3.09） were obviously lower in the treatment group （both P〈0.01）. The incidences of liver damage, high blood sugar, low blood potassium and metabolic acidosis in treatment group were significantly lower than those in control group （liver damage ： 23.85% vs. 36.45%, high blood sugar ： 23.85% vs. 39.25%, low blood potassium ： 4.59% vs. 19.63%, metabolic acidosis ： 17.43% vs. 35.51%, P〈0.05 or P〈 0.01） ; the incidences of myocardial damage and heart failure were lower than those in control group （myocardial injury ： 15.60% vs. 24.30%, heart failure ： 6.42% vs. 10.28%）, but the differences were not statistically significant （both P〉0.05）. The cure rate in treatment group was higher than that in control group （88.07% vs. 72.90%, P〈 0.01）. Conclusion Using internal environmental stabilization method for treatment of children with high fever and super high fever can significantly ameliorate the internal environment disturbances in the organism and reduce the incidences of complications, in the mean time the therapeutic course is shortened and the therapeutic effects are elevated, thus it is an economic and effective method worthwhile to be widely used in clinic.
出处
《中国中西医结合急救杂志》
CAS
北大核心
2012年第3期165-168,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
关键词
高热
超高热
儿童
内环境稳定治疗
High fever
Super high fever
Child
Environmental stability treatment
