摘要
近年来,生物靶向治疗越来越多地应用于自身免疫性疾病患者的治疗,并取得了较好的疗效。系统性红斑狼疮(SLE)是一种多系统受累的自身免疫病,患者体内存在多种免疫紊乱。目前治疗SLE的生物制剂包括去除B细胞、抑制T-B细胞间相互作用以及拮抗炎性细胞因子和B细胞活化因子等方面的药物。本文简要介绍已经上市和正在进行临床试验的SLE生物靶向治疗药物。
In recent years,biological therapy has increasingly been used in treating patients with autoimmune diseases.Systemic Lupus erythematosus（SLE） is a prototypic systemic autoimmune disease,characterized by disfunction of lymphocytes and production of various autoantibodies.Targeted biological agents for SLE include B cell depletion,interruption of T-B reaction,inhibition of pro-inflammatory cytokines or B cell activation factor,et al.Here we briefly introduce some promising biological agents for treating SLE patiens.
出处
《中华临床免疫和变态反应杂志》
2012年第2期85-87,共3页
Chinese Journal of Allergy & Clinical Immunology
关键词
生物治疗
红斑狼疮
系统性
biological therapy
lupus erythematosus,systemic
