摘要
目的比较缬沙坦联合氢氯噻嗪与单独应用缬沙坦治疗原发性高血压的临床疗效,从而指导临床治疗。方法将本院收治的86例原发性高血压患者随机分为实验组和对照组,实验组患者与对照组患者均给予80 mg/d剂量的缬沙坦治疗,实验组在此基础上给予12.5 mg/次、2次/d的氢氯噻嗪,治疗8周后,比较两组患者的临床治疗有效率及不良反应的发生率。结果实验组治疗后收缩压、舒张压均显著低于对照组(P<0.05),实验组患者治疗后总有效率为90.7%,不良反应发生率为4.7%;对照组患者治疗后总有效率为79.1%,不良反应的发生率为4.7%;实验组总有效率显著高于对照组(P<0.05),两组患者的脉压、不良反应发生率差异无统计学意义(P>0.05)。结论缬沙坦联合氢氯噻嗪治疗原发性高血压与单独应用缬沙坦相比,能够显著提高治疗的有效率,且不良反应轻微,安全性较好。
Objective To compare the clinical efficacy between valsartan combined hydrochlorothiazide and valsartan alone in treating essential hypertension, to guide the clinical treatment. Methods Eighty-six patients with essential hypertension in our hospital were randomly divided into experimental and control group. The experimental group and control group pa- tients were given 80 mg/d dose of valsartan, and the experimental group was given hydrochlorothiazide, 12.5 mg one time, 2 times a day. After 8 weeks of treatment, the clinical effective rate and the incidence of adverse reactions were compared. Results After treatment, SBP and DBP of the experimental group was significantly lower than that of control group （P 〈 0.05）, the clinical total effective rate and the incidence of adverse reactions of the experimental group were 90.7% and 4.7%, while the control group were 79.1% and 4.7%. The clinical total effective rate of experimental group was significantly high- er than that of control group （P 〈 0.05）, while there was no significant difference in incidence of adverse reaction and pulse pressure between two groups （P 〉 0.05）. Conclusion Valsartan combined with hydrochlorothiazide treatment for essential hypertension can significantly improve the treatment efficiency, and its adverse reactions are mild and of good safety.
出处
《中国当代医药》
2012年第19期101-102,共2页
China Modern Medicine
关键词
缬沙坦
氢氯噻嗪
高血压
临床疗效
Valsartan
Hydrochlorothiazide
Hypertension
Clinical efficacy
