摘要
目的 研究肾素 -血管紧张素转换酶 (ACE)基因多态性与脑梗死的关系。方法 通过 PCR方法研究 76例脑梗死患者 (其中高血压患者 5 1例 )及 30例健康对照者的 ACE基因。结果 脑梗死组 DD/II基因型显著增高 /降低 (P<0 .0 5 ,P<0 .0 1) ,尤其伴高血压的脑梗死患者这种趋势更为明显。结论 ACE基因多态性和高血压脑梗死患者有关联性 ,DD基因型提示可能与高血压患者发生脑梗死有关 ,而
Objective To investigate the relationship between the polymorphism of the renin angiotensin converting enzyme(ACE) gene and cerebral infarction.Methods To study ACE gene in 76 patients with cerebral infarction(among which 51 patients with hypertension) and 30 controls by polymeaser chain reaction(PCR).Results DD/II genotype was significantly higher/lower in the infarction group( P <0.05, P <0.01).And the same trends have been especially shown in hypertensive cerebral infarction.Conclusion There was correlationship between ACE gene polymorphism and the patients with hypertension cerebral infarction,DD genotype was possibly involved in the development of cerebral infarction in the patients with hypertension,angiotensin II was a protective genotype.
出处
《临床神经病学杂志》
CAS
2000年第1期19-21,共3页
Journal of Clinical Neurology
关键词
高血压
多态性
脑梗塞
ACE
Cerebral infarction Hypertension Renin angiotensin converting enzyme gene Polymorphism
