摘要
新方法合成头孢噻肟酸采用新旧工艺交叉组合优化,新方法对溶解后的7-ACA进行萃取分相,去除其中的杂质,然后在与AE-活性酯在催化剂的催化下反应生成头孢噻肟酸。有效地将头孢噻肟酸合成工艺进行了改进,得到的头孢噻肟酸单杂<0.8%,总杂<1.4%。使用杂质低的头孢噻肟酸制成头孢噻肟钠成品的吸光度(430nm波长)有了很大的改善。
The new method of the synthesis of Cefotaxime Acid use new and old technology cross and com- bination optimization, New method extraction points in dissolved 7--ACA, removal of impurities, Then the MAEM ester under the catalysis of catalyst in the reaction of Cefotaxime Acid. Effective Cefotaxime Acid synthesis process improvement, Get Cefotaxime Acid single impurity 〈0.8%, total impurities 〈1. 4%. The Cefotaxime Sodium which made of low impurities Cefotaxime Acid has improved a lot in 430nm wavelength＇s absorbance.
出处
《河北省科学院学报》
CAS
2012年第1期74-77,共4页
Journal of The Hebei Academy of Sciences
关键词
7-ACA
合成
催化剂
头孢噻肟酸
单杂
总杂
7 -- ACA
Synthesis
Catalyst
Cefotaxime Acid
Single impurity
Total impurities
