摘要
目的利用TiO2的抗菌特性,开发一种能够应用于口腔的无机抗菌材料。方法采用射频磁控溅射法在医用不锈钢表面制备TiO2-xNx薄膜,用XRD、SEM、EDS等测试手段表征薄膜的结构、形貌、组成,并通过覆膜法利用口腔常见致病菌考察TiO2-xNx薄膜的抗菌性能。结果纳米TiO2-xNx抗菌薄膜为锐钛矿相结构,氮元素质量比为0.13%,表面结构均匀致密,对变形链球菌、粘性放线菌及白色念珠菌的抗菌率分别为97.79%、49.42%和96.84%。结论纳米TiO2-xNx抗菌薄膜对口腔常见致病菌具有较强的抗菌效果,可作为一种新型抗菌剂应用于口腔临床。
Objective To prepare a nano-TiO2 film and characterize its antibacterial properties for dental application. Methods The TiO2-xNx antibacterial film was prepared by radio frequency （RF） magnetron sputtering. The crystal structure and surface morphology of the film were characterized by X-ray diffraction, scanning electron microscopy, and EDS, and the antibacterial properties of the film against common dental pathogenic bacteria were evaluated. Results The TiO2-xNx antibacterial film presented with an anatase phase with a mass ratio of nitrogen of 0.13% and compact and smooth surface. Antibacterial assay of the film showed a resistance rate of 97.79% against Streptococcus mutans, 49.42% against Actinomyces viscosus, and 96.84% against Candida albicans. Conclusion The nano-TiO2-xNx film shows strong antibacterial effects against common dental pathogenic bacteria and can be used as a novel antibacterial dental material.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2012年第7期952-955,共4页
Journal of Southern Medical University
基金
国家杰出青年基金(50925206)
甘肃省国际科技合作基金(090WCGA903)
教育部春晖计划(Z2008-1-62007)
中央高校基本科研业务费专项资金(lzujbky-2010-83)~~
关键词
纳米掺氮二氧化钛
薄膜
抗菌
nano-TiO2-xNx films
antibacterial properties
dental materials
