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非小细胞肺癌抗-Survivin抗体阳性与阴性患者术后生存期比较的临床研究

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摘要 目的探讨非小细胞肺癌抗-Survivin抗体阳性与阴性患者术后生存期差异。方法用酶联免疫吸附(ELISA)检测260例非小细胞肺癌(NSCLC),高于对照组均值2个标准差作为确定非小细胞肺癌抗存活素抗体阳性的诊断标准:1.3946+2×0.0846=1.56U/ml。在非小细胞肺癌中表达率51.5%,阳性患者134例,手术组69例,化疗组65例。阴性患者126例,手术组62例,化疗组64例。其中69例抗-Sur-vivin抗体阳性患者和抗-Survivin抗体阴性患者62例行手术治疗。结果抗-Survivin抗体阳性NSCLC患者血清抗-Survivin抗体的浓度是(2.1009±0.7342)U/ml,抗-Survivin抗体阴性NSCLC患者血清抗-Survivin抗体的浓度(1.3946±0.0646)U/ml,NSCLC患者血清抗-Survivin抗体阴性组的生存期比阳性组明显要长,差异有统计学意义(P<0.05)。结论 NSCLC患者血清抗-Survivin抗体浓度与生存期有明显的相关性。
出处 《河北医药》 CAS 2012年第11期1628-1629,共2页 Hebei Medical Journal
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