摘要
神经内分泌肿瘤(NEN)起源于胺前体摄取与脱羧酶细胞,胃肠道是NEN最常见的发病部位。其生物学特性、恶性程度、病理学特征及预后差异很大,多数患者缺乏典型临床表现。常用的治疗方法包括手术切除、化学治疗、放射治疗及内镜和介入治疗等。另外,一些新的靶向药物展现了良好的应用前景。目前,对于本病的治疗和预后,国内外学者尚缺乏统一认识。
Neuroendocrine neoplasm（NEN）is derived from cells of amine precursor uptake and decarbosylase（APUD）.Gastrointestinal tract is the predilection site of NEN.There is considerable variability in the biological characteristics,grade of malignancy,pathological characteristics and prognosis.Most of the patients have no typical clinical manifestations.Common treatments include surgery,chemotherapy,radiotherapy,endoscopic and radiological intervention.In addition,novel therapies targeting deregulated pathways in tumors may offer therapeutic promise.However,unified understanding on the therapy and prognosis of NEN has not been reached in domestic and foreign research field yet.
出处
《医学综述》
2012年第11期1672-1674,共3页
Medical Recapitulate
关键词
胃肠道肿瘤
神经内分泌肿瘤
临床特点
治疗
Gastrointestinal tumours
Neuroendocrine neoplasm
Clinical features
Therapy
