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血清可溶性B7-H4在非小细胞肺癌患者中的表达及临床意义 被引量：4

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摘要 目的研究血清可溶性B7-H4(sB7-H4)在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法应用ELISA法检测51例NSCLC与40例肺部良性疾病(BPD)患者sB7-H4的表达水平,并分析手术前后sB7-H4的变化情况;通过电化学发光法检测CA125、CEA在NSCLC血清中的表达水平,分析其与sB7-H4的相关性。结果NSCLC患者sB7-H4水平(49.78±13.46)μg/L高于BPD患者(17.34±9.39)μg/L(P<0.01),且NSCLC患者sB7-H4水平与CA125、CEA水平呈正相关(P<0.01)。NSCLC患者术后sB7-H4水平低于术前水平(P<0.05)。NSCLC患者sB7-H4水平与组织分化、TNM分期及淋巴结转移有关,P均<0.05。结论 sB7-H4可能参与NSCLC的发生发展及转移,有望成为NSCLC免疫治疗的一个新靶点。
作者 张波 买买提.吐尔逊木明 庞作良
机构地区 新疆医科大学附属肿瘤医院 新疆医科大学研究生院
出处 《山东医药》 CAS 2012年第20期84-86,共3页 Shandong Medical Journal
关键词 癌 非小细胞肺 肺癌根治性手术 sB7-H4 CA125 CEA
分类号 R734.2 [医药卫生—肿瘤]
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参考文献13

  • 1Shin T, Kennedy G, Gorski K, et al. Cooperative B7-1/2 (CD80/ CD86) and B7-DC costmiulation of CD+ T cells independent of the PD-1 receptor [J]. J Exp Med, 2003,198(1 ) :31-38.
  • 2Chert L. Co-inhibitory molecules of the B7-CD28 family in the con- trol of T-cell immunity [ J ]. Nature Rev Immunol, 2004,4 ( 5 ) :336-347.
  • 3Sica GL, Choi IH, Zhu G, et al. B7-H4, a molecule of the B7 fam- ily, negatively regulates T cell immunity [J]. Immunity, 2003,18 (6) :849-861.
  • 4葛蕙心,畅继武.B7-1、GPI及其拼接在肿瘤免疫治疗中的应用进展[J].山东医药,2006,46(29):78-79. 被引量：2
  • 5Simon I, Zhuo S, Corral L, et al. B7-h4 is a novel membrane- bound protein and a candidate serum and tissue biomarker for ovari- an cancer [J]. Cancer Res, 2006,66(3) :1570-1575.
  • 6Simon I, Katasaros L, Riqault de la Lonqrais I, et al. B7-H4 is o- ver-expressed in early stage ovarian cancer and is independent of CA125 expression [ J ]. Gynecol Oncol, 2007,106 ( 2 ) : 334-341.
  • 7Kryczek I, Wei S, Zhu G, et al. Relationship between B7-H4, reg- ulatory T ceils, and patient outcome in human ovarian carcinoma [ J ]. Cancer Res, 2007,67 ( 18 ) : 8900-8905.
  • 8孔凡荣,王黎明,戴淑真,孙显璐,王昱洁.B7-H4在上皮性卵巢癌中的表达及临床意义[J].山东医药,2008,48(46):32-33. 被引量：5
  • 9Salceda S, Tang T, Kmet M, et al. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation [ J]. Exp Cell Res, 2005,6 ( 1 ) : 128-141.
  • 10Thompson RH, Zang X, Lohse CM, et al. Serum-soluble B7x is elevated in renal cell carcinoma patients and is associated with ad- vanced stage [J]. Cancer Res, 2008,68(15) :6054-6058.

二级参考文献62

共引文献18

同被引文献32

  • 1钱运智,陈卫红,王秀兰,杨德娟,陈镜琼.接尘工人肺癌患者胸片分析[J].同济医科大学学报,1995,24(3):205-205. 被引量：4
  • 2Awadallah NS,Shroyer KR,Langr RA,et al. Detectionof B7-H4 and p53 in pancreatic cancer : potential roleas a cytological diagnostic adjunct [ J ]. Pancreas ,2008,36(2) :200-206.
  • 3Wang JC,Sone S,Feng L. Rapidly growing small peripheral lung cancers detected by screening CT:correlation between radiological appearance and pathological features[J].British Journal of Radiology,2000,(873):930-937.
  • 4Aoki T,Nakata H,Watanabe H. Evolution of peripheral lung adenocarcinomas:CT findings correlated with histology and tumor doubling time[J].American Journal of Roentgenology,2000,(03):763-768.
  • 5Seemann MD,Beinert T,Fürst H. An evaluation of the tumour markers,carcinoembryonic antigen(CEA),cytokeratin marker(CYFRA 21-1) and neuron-specific enolase(NSE)in the differentiation of malignant from benign solitary pulmonary lesions[J].Lung Cancer,1999,(03):149-155.doi:10.1016/S0169-5002(99)00084-7.
  • 6Yoshizawa A, Motoi N, Riely GJ, et al. Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognos- tic subgroups and implications for further revision of staging based on analysis of 514 stage I cases[J].Mod Pathol, 2011, 24 ( 5 ) : 653 - 64.
  • 7Chen C, Qu QX, Shen Y, et al. Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macropha- ges : a potential mechanism of immune escape [ J ]. Cancer Lett, 2012, 317(1) : 99 -105.
  • 8Qian Y, Hong B, Shen L, et al. B7-H4 enhances oncogenicity and inhibits apoptosis in pancreatic cancer cells [ J ]. Cell Tissue Res, 2013, 353(1): 139-51.
  • 9Liu W, Shibata K, Koya Y, et al. BT-H4 overexpression corre- lates with a poor prognosis for cervical cancer patients [ J ]. Mol Clin Oncol, 2014, 2(2) : 219 -225.
  • 10Sun SQ, Jiang CG, Lin Y, et al. Enhanced T cell immunity by B7-H4 downregnlation in nonsmall-cell lung cancer cell lines [ J]. J Int Med Res, 2012, 40(2) : 497 -506.

引证文献4

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山东医药
2012年 第20期

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