摘要
蛇床子总香豆素具有松驰由药物引起的支气管痉挛和直接扩张支气管的作用,这一作用均能被β-受体阻滞剂心得安所阻断。此外,蛇床子总香豆素对麻醉动物无加快心率和升高血压的作用。提示蛇床子总香豆素的解痉作用可能是通过兴奋β_2-受体所致。
Total coumarins in the fruit of Cnidium monnieri show a marked protective effect against hronchial asthma induced by inhalation of histamine in conscious guinea pig. In vitro these total coumarins can relax the contraction of the isolated trachea in guinea pigs induced by histamine as well as increase the perfusion rate of isolated lung preparation of guinea pig. These actions, however, may be bloeked by propranolol. Besides, these coumarins cannot increase the heart rate and arterial blood pressure in anesthetized rats. All this shows that the antiasthmatic effect of total coumarins in the fruit of Cnidium monnieri is mediated by β_2-receptor.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1990年第5期48-50,共3页
China Journal of Chinese Materia Medica
关键词
蛇床子
总香豆素
止喘
心得安
total coumarins in the fruit of Cnidium monnieri
bronchus
antiasthmatic
β_3-receptor
propranolol
