摘要
目的探讨阿魏酸钠对糖尿病患者早期肾损害的治疗价值。方法将80例伴有微量白蛋白尿的2型糖尿病患者随机分为常规治疗组(RTG组)和阿魏酸钠治疗组(SFG组)。比较治疗前后血脂、内皮素-1(ET-1)、血尿β2-微球蛋白(β2-MG)及尿微量白蛋白(Alb)的变化。结果与治疗前比较,SFG组血尿β2-MG、尿Alb及血ET-1均显著降低(P<0.01),并且脂质代谢紊乱亦有改善;而RTG组血尿β2-MG、尿Alb及血ET-1治疗前后比较,差异无统计学意义(P>0.05)。结论阿魏酸钠治疗能改善血管内皮功能,逆转糖尿病患者的早期肾损害。
Objective To observe the effect of sodium ferulate on early renal damage in patient with diabetic nephropathy.Methods 80 cases with microalbuminuria in patients with type 2 diabetes were randomly divided into routine treatment group（RTG） and sodium ferulate treatment group（SFG）,The changes of the lipids,endothelin-1,serum β2-microglobulin and urinary β2-microglobulin,urine microalbumin before and after treatment were compared between the two groups.Results After the treatment,the levels of serum β2-microglobulin and urinary β2-microglobulin,urine microalbumin and endothelin-1 in the SFG significantly decreased（P〈0.01）,and the disorder of lipid metabolism improved;the levels of serum β2-microglobulin and urinary β2-microglobulin,urine microalbumin and endothelin-1 in RTG had no statistical difference before and after treatment（P〈0.01）.Conclusion Treatment of sodium ferulate can improve vascular endothelial function,reverse the early renal damage in patients with diabetic.
出处
《内科》
2012年第3期227-229,共3页
Internal Medicine
关键词
糖尿病
内皮素-1
肾功能
阿魏酸钠
Diabetic
Endothelial-1
Kidney function
Sodium ferulate
