摘要
应用特异的兔抗豚鼠血小板血清耗竭脉鼠血小板，再予以卵白蛋白攻击后，诱发气道速发型变态反应，发现血小板耗竭后可明显抑制卵白蛋白所致的肺阻力增高，但对肺动态顺应性无明显影响，说明血小板在豚鼠气道速发型变态反应中起主要作用，推测其作用部位主要在大气道血小板活化因子的拮抗剂ＷＥＢ２０８６不能对抗卵白蛋白所致的肺阻力增高和肺动态顺应性的下降，而阿魏酸钠对此有抑制作用。
The effects of platelet depletion withrabbit anti-guinea pig platelet serum on the airway im-mediate hypersensitivity induced by ovalbumin in guinea pigs were investigated. Platelel depletion inhibitedenhanced ovalbumin-induced lung resistance. but hadno effect on lung dynamic compliance. suggesting thatplatelets might play an important role in the airway im-mediate hypersensitivity in guinea pig and mainly af-fect the large airway. Platelets activating factor (PAF)is not a major niediator in the airway immediatehypersensitivity. because PAF antagonist. WEB2086,did not inhibit enhanced ovalbumin induced lung re-sistance and decreased lung dynamic compliance, butsodium ferulate did. suggesting sodium ferulate mighthavc anti allergic effect, though it has no effect onPAF induced bronchospasm.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1994年第4期256-259,共4页
Chinese Journal of Pharmacology and Toxicology
