摘要
研究噻二唑类杂环化合物对人白血病K562癌细胞的体外抗肿瘤活性筛选。方法:利用MTT法间接测定各化合物对肿瘤细胞后的生长情况,并计算出肿瘤细胞的抑制率,选择抑制率较高的化合物进行深入研究,计算其半数抑制浓度(IC50),并考察其浓度-生长率线性关系。结果:大部分化合物均显示了较好的人白血病K562癌细胞抑制活性,化合物1抑制率达92.01%,IC50为7.07×10-5mol/L,浓度-生长率R2=0.986。结论:噻二唑类杂环化合物具有较好的抗肿瘤活性。
Objective： to study the antitumor activity of some thiadiazole compounds. Methods： to detect the growth of tumor cell indirectly by MTT method and calculate the inhibition rate. The IC50 and the linear relation- ship between concentration - the growth rate of the compound with highest inhibition is also investigated. Re- suits： most compounds show good inhibitory activity against human leukemia K562 cell, and the inhibition rate of compound One is 92.01% with ICs07.07×10-5 mol/L the linear relationship between concentration - the growth rate R2 is 0.986. Conclusion ： the thiadiazole compounds show good antitumor activity against K562 cell.
出处
《安徽科技学院学报》
2012年第2期48-51,共4页
Journal of Anhui Science and Technology University
基金
安徽省教育厅高校省级自然科学研究项目(KJ2011B154)
