摘要
目的:评价根除幽门螺杆菌(Hp)治疗对胃黏膜的影响。方法:在Pubmed、Embase和中国期刊数据库中检索研究根除Hp与慢性萎缩性胃炎及肠上皮化生关系的随机对照临床试验,对这些文献进行资料质量评价,并对符合的文献进行荟萃分析。结果:7篇文献(包括3414例患者)符合入选标准,治疗组和对照组慢性萎缩性胃炎逆转率分别为10.15%和3.29%,相对危险度(RR)为4.02(95%CI,2.03～7.96;P<0.0001),差异有统计学意义;肠化生逆转率根除组和对照组分别为17.79%和12.34%,相对危险度为1.74(95%CI,0.68～4.46;P=0.25),差异无统计学意义;肠化生进展率根除组和对照组分别为21.25%和19.49%,相对危险度为0.82(95%CI,0.48～1.40;P=0.47),差异无统计学意义。结论:根除Hp后萎缩性胃炎能逆转,但根除Hp不能阻止肠化生进展。
Objective： To evaluate the impact of helicobacter pylori eradication on chronic atrophic gastritis and intestinal metaplasia.Methods： A systematic review of all relevant randomized controlled trials was performed.Results：7 documents with 3414 subjects met the inclusion criteria（Jadad score≥3）.There was a significant difference of regression of chronic atrophic gastritis（CAG） between treatment group and control group,RR=4.02（95%CI,2.03～7.96,P0.0001）.There was no significant difference of regression or progression of interstinal metaplasia（IM） between treatment group and control group,RR=1.74（95%CI,0.68～4.46;P=0.25）.RR=0.82,（95%CI,0.48～1.40;P=0.47）.Conclusions：Gastric atrophy improved significantly after control of H.pylori infection,but eradication of Hp did not prevent the progression of interstinal metaplasia.
出处
《中医临床研究》
2012年第11期117-120,共4页
Clinical Journal Of Chinese Medicine
关键词
慢性萎缩性胃炎
肠上皮化生
幽门螺杆菌
根除治疗
荟萃分析
Chronic atrophic gastritis
Intestinal metaplasia
Helicobacter pylori
Eradication
Meta-analysis
