摘要
目的 研究婴幼儿接种国产BRDⅡ株风疹减毒活疫苗后的免疫持久性。方法 以血凝抑制 (HI)抗体方法 ,选择城区既往无风疹感染和风疹疫苗免疫史的 6～ 18月龄组婴幼儿 ,对其接种风疹疫苗 1年和 2年后的抗体水平进行检测。结果 在 6、7、8、9、12和 18月龄组初免获得成功的儿童中 ,接种风疹疫苗 1年和 2年后 ,各组HI抗体阳性率仍分别高达 94.44 %、97.2 2 %、96 .6 7%、10 0 .0 0 %、10 0 .0 0 %、10 0 .0 0 %和 93.10 %、93.5 5 %、96 .77%、 96 .97%、10 0 .0 0 %、10 0 .0 0 % (P >0 .0 5 ) ,但免后 1年和 2年的GMRTs则分别较免后 1个月和免后 1年约降低了 5 0 % ,且免后 2年 6～7月龄组的GMRTs(2 9.89)显著低于 8～ 18月龄组 (5 3.0 0 )的结果 (t =3.5 8,P <0 .0 0 1)。结论 国产风疹疫苗起始免疫月龄不宜太小 ,以儿童出生后 8月龄为宜 。
Objective To study the immuno persistence after inoculating with the domestic BRDⅡ strain rubella vaccine among infants and young children. Methods Hemagglutination inhibition (HI) antibody detection method was used to test on children at age 6 to 18 months without rubella infection or rubella vaccine immunization in Yantai city of Shandong province and were selected for the observation of the immuno persistence against the domestic BRD Ⅱ strain rubella vaccine from 1995 to 1998. Results Positive rates of HI antibody among children of 6,7,8,9,12 and 18 month old of inoculation were 94.44 %, 97.22 %, 96.67 %, 100.00 %, 100.00 %, 100.00 % and 93.10 %, 93.55 %, 96.77 %, 96.97 %, 100.00 %, 100.00 % ( P > 0.05 ),in one or two years nespectively. The geometric mean reverse titers (GMRTs) were about 50% lower than that after 1 month after 1 year. Similar resutls were found that after 2 years GMRTs was about 50% lower than that after 1 year of inoculation. There was highly significant difference on GMRTs of HI antibody between infants with 6 to 7 month olds (29.89) and young children with 8 to 18 month olds (53.00) after 2 years of inoculation ( t =3.58, P <0.001). Conclusion The immunization schedule at the first dose for BRDⅡ strain rubella vaccine should be started when the child is 8 month old. For the second dose, the immunization schedule used in other developed countries should be referred adopted in China.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2000年第2期117-120,共4页
Chinese Journal of Epidemiology
关键词
风疹疫苗
免疫持久性
血凝抑制抗体
婴幼儿
Rubella vaccine
Immuno persistence
Hemagglutination inhibition antibody
