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调节性B细胞在炎症免疫相关疾病的调控作用及机制 被引量：6

Regulation and mechanisms of regulatory B cell in inflammation and immune related diseases
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摘要 调节性免疫细胞具有广义和狭义概念,狭义上,调节性免疫细胞是指具有负性调节作用的免疫细胞。调节性B细胞(regulatory B cell,Breg)在控制炎症免疫相关疾病免疫应答、介导免疫耐受中可能发挥重要作用。Breg通过分泌抑制性细胞因子IL-10和TGF-β负性调控炎症免疫相关疾病的病理过程。TLRs/MyD88信号转导通路在介导Breg功能中起到关键作用。TLRs/MyD88信号转导活化促进Breg细胞产生IL-10,抑制T细胞活化及IFN-γ分泌。不同TLR控制着炎症免疫相关疾病的启动和恢复。运用优先触发Breg细胞调节功能的TLR激动剂,分离TLRs的相反作用,对控制免疫反应,制定合理的炎症免疫相关疾病治疗策略具有重要的意义。 Regulatory immune cells have generalized and narrowed concepts.Regulatory immune cells are defined the cells with negative regulatory function in narrowed concepts.Regulatory B cell（Breg） plays an important role in controlling immune response,and mediating immune tolerance for inflammation and immune related diseases.Breg down-regulates the pathological progress of inflammation and immune related diseases through the inhibitory cytokines of IL-10 and TGF-β.TLRs/MyD88 signaling plays a key role in Breg function.The activation of TLRs/MyD88 signaling promotes IL-10 production and inhibits T cells activation and IFN-γ secretion.Different TLRs control the initiation and resumption.It will be significant for controlling immunoreaction,establishing rational therapeutic strategy of inflammation and immune related diseases by using TLR agonists to touch preferentially the regulating function of Breg,and separate oppositional function of TLRs.
作者 张玲玲 魏伟
机构地区 安徽医科大学临床药理研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2012年第7期889-893,共5页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No 30973543 31100640 81173075) 安徽省自然科学基金资助项目(No11040606M195)
关键词 调节性免疫细胞 调节性B细胞 炎症免疫相关疾病 TOLL样受体 信号转导 天然免疫 适应性免疫 regulatory immune cells； regulatory B cell； inflammation and immune related diseases； TLRs； signaling； innate immunity； adaptive immunity
分类号 R-05 [医药卫生] R364.5 [医药卫生—病理学]
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参考文献34

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同被引文献50

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中国药理学通报
2012年 第7期

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