摘要
目的探讨乳果糖对非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)患者肠道通透性的干预作用。方法选择健康正常成人30例作为正常对照组(A组),非酒精性脂肪性肝炎共60例,随机分为NASH对照组(B组)和乳果糖干预组(C组)各30例,其中C组给予乳果糖(10 mL/d)进行干预。检测所有被研究者的血清内毒素、二胺氧化酶(diamine oxidase,DAO)、D-乳酸及ALT的浓度。干预4周后,再次检测B、C两组的血清内毒素、二胺氧化酶(DAO)、D-乳酸及ALT的浓度。结果与A组比较,治疗前B、C两组内毒素、DAO、D-乳酸水平显著增高(P<0.01),B组干预前后比较,内毒素、DAO、D-乳酸及ALT水平无显著改变(P>0.05),而C组干预前后比较,内毒素、DAO、D-乳酸及ALT水平显著降低(P<0.01)。结论 NASH患者血清内毒素水平及肠道通透性增高,乳果糖可降低NASH患者肠道的通透性及血浆内毒素水平。
Objective To investigate intervention effect of lactulose on intestinal permeability in patients with nonal- coholic steatohepatitis （NASH）. Methods Thirty healthy adults and sixty patients with NASH were divided into 3 groups： health group （group A）, NASH control group （group B, 30 patients） and laetulose treated group （group C ,30 patients）. Their serum endotoxin, diamine oxidase, D-Lactate and ALT levels were measured respectively. The group C was treated with lactulose（10 mL/d）. After 4 weeks treatment, their serum endotoxin, diamine oxidase, D-Lactate and ALT levels were detected again in group B and C. Results Compared with group A, serum endotoxin, diamine oxidase and D-Lactate levels increased （P 〈0.01 ） in group B and C. Four weeks later, serum endotoxin, diamine oxidase, D- Lactate and ALT levels decreased remarkably （P 〈 0.01 ） in group C, but they did not change obviously in group B （P 〉 0.05）. Conclusion Lactulose could effectively decrease intestinal permeability and levels of serum endotoxin in patients with NASH.
出处
《胃肠病学和肝病学杂志》
CAS
2012年第6期564-566,569,共4页
Chinese Journal of Gastroenterology and Hepatology
