摘要
Objective To study the potential role of macrophage migration inhibitory factor(MIF),Interleukin-17(IL-17) and Interleukin-10(IL-10) in the development of HBV-related liver disease.Methods 48 patients with chronic hepatitis B(HBeAg negative and positive,24 cases;21cases of HBV-DNA negative and 27 cases of HBV-DNA positive),81 cases of hepatitis B patients with decompensated cirrhosis and 48 cases of primary liver cancer patients were collected as the experimental group,26 healthy people were as control group.Serum MIF,IL-17 and IL-10 were measured.Results MIF and IL-17 significantly increased,IL-10 significantly decreased in experimental group,compared with the control group(P<0.05),there was significant difference.In addition,there was no significant difference(P>0.05) between positive and negative of chronic hepatitis B.MIF,IL-17 and ALT levels were positively correlated(r=0.693,P<0.01;r=0.897,P<0.001),IL-10 and ALT was negatively correlated(r =-0.285,P=0.037).Conclusion These results indicated that MIF,IL-17 and IL-10 may participate in the pathological process of HBV-related liver disease,serum levels of MIF,IL-17 and IL-10 appear to reflect the severity of tissue injury in HBV-related liver disease.
Objective To study the potential role of macrophage migration inhibitory factor （MIF）, Interleukin-17 （IL-17） and Interleukin-10 （IL-10） in the development of HBV-related liver disease. Methods 48 patients with chro- nic hepatitis B （HBeAg negative and positive, 24 cases; 21cases of HBV-DNA negative and 27 cases of HBV-DNA pos- itive） , 81 cases of hepatitis B patients with deeompensated cirrhosis and 48 cases of primary liver cancer patients were collected as the experimental group, 26 healthy people were as control group. Serum MIF, IL-17 and IL-10 were meas- ured. Results MIF and IL-17 significantly increased, IL-10 significantly decreased in experimental group, compared with the control group （P 〈 0.05） , there was significant difference. In addition, there was no significant difference （P 〉 0.05） between positive and negative of chronic hepatitis B. MIF, IL-17 and ALT levels were positively correlated （r=0.693, P〈O. 01; r=0.897, P〈O. O01）, IL-IO and ALT was negatively correlated （r = -0. 285, P=0.037）. Conclusion These results indicated that MIF, IL-17 and IL-10 may participate in the pathological process of HBV-re- lated liver disease, serum levels of MIF, IL-17 and IL-10 appear to reflect the severity of tissue injury in HBV-related liver disease.
出处
《胃肠病学和肝病学杂志》
CAS
2012年第6期560-563,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
supported by grants from the Natural Science Foundation of Gansu Province of China
