摘要
以移行性综合肌电(MMC)作指标,研究红霉素(EM)消化道副作用与平滑肌电活动的关系。结果发现,在狗消化间期,静脉注射EM50～400μg/kg,在3～7min内即诱发剂量依赖性早发MMCⅢ相。此早发Ⅲ相起于胃、十二指肠,向小肠尾端移行,其锋电发生率、Ⅲ相持续时间和移行速度等均与自发Ⅲ相类似。胃、十二指肠内分别注射EM500μg/kg,经24.5±7.5min和23.7±2.2min才诱发移行性Ⅲ相。双侧膈上迷走神经切除后,EM仍诱发早发Ⅲ相,但其移行速度减慢(p<0.01),阿托品能阻断EM诱发Ⅲ相的发生。EM在Ⅲ相诱发后的70～250min甚至更长时间内仍使MMC周期和Ⅲ相起始紊乱,甚至完全破坏MMG,代之以超速扩布锋电簇活动。EM不影响进食后狗的胃肠电活动。因此,EM消化道反应的发生可能与其被吸收进血液后通过内在胆碱能神经启动早发Ⅲ相及其后较长后效应有关。
We studied the effect of erythromycin (EM) on the migrating myoelectric complex (MMC)in dogs and found that 30-40 min after phase-Ⅲ occurring in the duodenum, intravenous injection of EM lactobionate at doses of 50-400μg/kg induced dose-dependent premature phase Ⅲ in 3-7 min, which were quite similar to the spontaneous phase Ⅲ in the frequency of spike bursts, migrating velocity and duration. Injection of EM 500μg/kg into the stomach and duodenum also initiated premature phase Ⅲ with latent periods of 24.5 ± 7.5 min and 23.7 ± 2.2 min respectively. Atropine pretreatment abolished EM-in-duced phase Ⅲ, but vagotomy did not. In a period of at least 70-250 min following premature phase Ⅲ, there was post-inducing effect of EM on the myoelectric activity, including shortened or prolonged MMG cycles, ectopic phase Ⅲ, even complete disruption of MMC and replacement of MMC by ultrarapid propagating bursts of spike activity. Anyway, EM had no effect on the gastrointestinal myoelectric activity in the digestive state of dogs.We consider that the side effect of EM on the gastrointestinal tract is associated with the premature phase HI and post inducing effect of EM. To induce phase Ⅲ, EM must be absorbed into the systemic circulation and exerts effect on the enteric cholinergic plexus.
出处
《中国应用生理学杂志》
CAS
CSCD
1990年第1期50-54,共5页
Chinese Journal of Applied Physiology
关键词
红霉素
MMC
肌电图
生物电
erythromycin
migrating myoelectric complex (MMC)
eiectromyogram
bioelec- tricity
