摘要
卵巢过度刺激综合征(OHSS)是促排卵过程中严重的医源性并发症,人绒毛膜促性腺激素诱导排卵使过多卵泡受刺激有关。其发病机制不明,病理生理特征主要为毛细血管通透性增加以及富含蛋白的液体停留在血管外间隙,导致血液浓缩,第三间隙水肿。现从血管内皮生长因子、血小板活化因子、溶血磷脂酸诱导炎性因子、囊性纤维化跨膜传导调节因子、肾素-血管紧张素系统对OHSS发病机制进行探讨分析,为临床更好地治疗和预防OHSS的发生提供理论依据。
The ovarian hyperstimulation syndrome （OHSS）is a serious iatrogenic syndrome of controlled ovarian hyperstimulation, related tohuman chorionie gonadotropin （ HCG ） induced ovulation caused follicles stimulation. Its pathogenesis is unknown, the main pathophysiological characteristics are increased capillary permeability and protein-rich liquid stasis in the extravascular space, resulting in blood concentration, third interstitial edema. Here is to discuss the possible pathogenesis of OHSS from the perspective of blood vessels endothelial growth factor, platelet-activating factor, lysophosphatidic acid-induced inflammatory factor, cystic fibrosis transmembrane conductance regulator, renin-angiotensin system, to provide a theoretical basis for bet- ter prevention and treatment of OHSS in clinic.
出处
《医学综述》
2012年第10期1534-1536,共3页
Medical Recapitulate
关键词
卵巢过度刺激
血管内皮生长因子
溶血磷脂酸
Ovarian hyperstimulation
Vascular endothelial growth factor
Lysophosphatidic acid
