摘要
为探讨钙拮抗剂对细胞大分子代谢的影响,观察了维拉帕米对[<sup>3</sup>H]TdR、[<sup>3</sup>H]UR和[<sup>3</sup>H]Leu参入人成纤维细胞的作用。维拉帕米抑制DNA和RNA合成的作用为浓度依赖性,ID<sub>50</sub>分别为12.3mg/L和22mg/L。对蛋白质合成的抑制作用较弱。
In order to investigate the action of calcium antagonists on metabolism of intracellular macromolecules, The authors observed the effects of verapamil on the incor-poration of 〔 3H 〕 TdR, 〔 3H 〕 UR and 〔 3H 〕 Leu into human fibroblasts. The inhibitory effects on DNA and RNA synthesis were concentration dependent, ID50 was l2.3mg/L and 22mg/L, respectively. The inhibitory effect on the synthesis of protein was weak.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1990年第1期50-51,共2页
Chinese Pharmacological Bulletin
关键词
维拉帕米
钙拮抗剂
核酸
蛋白
Calcium antagonists
Verapamil
Nucleic acid
Protein, 〔~3H〕 Thymidine
〔~3H〕 Uridine
〔~3H〕 Leucine
