摘要
目的 综述近年来国内外有关成纤维细胞与创伤修复、瘢痕形成的研究进展。方法 广泛查阅相关文献 ,对成纤维细胞在创伤修复过程中的细胞生物学、分子生物学行为进行整理、分析和综合。结果 通过生长因子等因素的调节 ,成纤维细胞在肉芽形成、伤口收缩、基质合成、伤口修复、瘢痕形成及无瘢痕愈合方面均起重要作用。结论 对成纤维细胞生物学行为的了解与调控将促进创伤修复和瘢痕防治的生物学治疗的发展。
Objective To review the recent advances in fibroblast study and its role in wound repair. Methods Recent original articles related to wound repair were retrieved extensively,and the effect of fibroblast on every stages of repair were sum med up and comprehended.Results Fibroblast plays im portant roles in granu- lation formation,wound contraction,matrix synthesis,wound repair,scar formation and scarless repair by means of growth factors m odulation.Conclusion The understunding of fibroblast in the wound repair can promote the progress of biological therapy of wound repair and scar prevention.
出处
《中国修复重建外科杂志》
CAS
CSCD
2000年第2期126-128,共3页
Chinese Journal of Reparative and Reconstructive Surgery
基金
四川省卫生厅科研基金
四川省中医药管理局科研基金! ( 963 2 0 0 )
