摘要
[目的]观察人宫颈癌基因(HCCR)的过度表达对评估乳腺癌患者预后的意义.[方法]选择105例因浸润性导管癌而行手术患者的肿瘤组织标本,采用免疫组织化学染色方法观察标本中HCCR、雌激素受体(ER)及孕酮受体(PR)的表达情况,分析HCCR表达与各组织学等级的关系、与ER,PR的相关性及与患者生存时间和生存率的相关性.[结果]105例乳腺癌患者中HCCR阳性表达率为26.7%.HCCR表达与临床分期、核异型性等级、核分裂、组织学等级及ER,PR表达均无相关关系.尽管呈HCCR的染色范围越广,患者的10年生存率越高的趋势,但无统计学意义.[结论]尚不能确定HCCR是乳腺癌的预后因子.
OBJECTIVE To study the overexpression of human cervical cancer oncogene（HCCR） for evaluate the prognostic significance of breast cancer patients.METHODS Expression of HCCR,estrogen receptor（ER）,progesterone receptor（PR） in 105 samples of surgically removed invasive ductal carcinoma of breast was observed by immunohistochemistry,and it was analyzed that the correlation between HCCR expression and each histologic grades,ER,PR and survival time and rate.RESULTS The positive expression rate of HCCR was 26.7% in 105 cases,and the expression of HCCR had no statistically significant correlation to stage,nuclear grade,number of mitosis,histologic grade,and expression of ER and PR.Although the staining range for the HCCR was wider,the survival rate of 10 years was higher trend,but the difference had no statistically significant.CONCLUSION It was not defined that HCCR can be as a prognostic factor of breast cancer.
出处
《延边大学医学学报》
CAS
2012年第1期13-15,共3页
Journal of Medical Science Yanbian University
关键词
乳腺肿瘤
人宫颈癌基因
预后
免疫组织化学
breast neoplasms
human cervical cancer oncogene
prognosis
immunohistochemistry
