摘要
目的评估冠状动脉疾病患者进行运动压力测试后血液中缺血修饰白蛋白的水平。方法选取本院49例一周内出现胸痛的患者，进行冠脉造影与单车运动压力测试，采集开始运动测试时的血液样本测试缺血修饰白蛋白，作为基线水平，5分钟后再次采样测试缺血修饰白蛋白水平。结果49例患者中，共中有25例（冠状动脉疾病组）有冠状动脉狭窄，另外24例（非冠状动脉疾病组）无冠状动脉狭窄。而缺血修饰白蛋白水平在基线水平与运动水平并无差异，冠状动脉疾病纽与非冠状动脉疾病组基线水平分别为70．7±7．2U／mL、72．5±6．4U／mL，而运动后水平为74．1±5．1、75．8±6．8U／mL，冠状动脉疾病组与非冠状动脉疾病组对比结果分别为P=0．28，P=0．55，二者无明显统计学差异。同时在运动后缺血修饰白蛋白水平变化值两组分别为5．4±3．5、4．7±7．6U／mL，P=0．10；同样的，在心电图阳性组（16例）与心电图阴性组（33例）缺血修饰白蛋白水平变化也无明显差异（6．6±3．IU／mL、7．50±4．2U／mL，P=0．15）。结论缺血修饰白蛋白在运动测试中对于急性冠脉综舍症的诊断并不适用。
Objective We examined the-ischemia- modified albumin （IMA） level during exercise in patients with coronary artery disease （CAD）. Methods 47 patients with a history of chest pain underwent both symptom - limited treadmill exercise stress testing and coronary an- giography within one week. During the treadmill tests, blood samples were obtained at baseline and 5 min after exercise to measure the serum IMA level. Results Of the 47 patients, 25 （53%, CAD group） had significant coronary artery stenosis, while the other 24 （47%, non - CAD group） did not. The baseline and post - exercise IMA levels in the two groups did not differ significantly （70.7 ± 7.2 U/mL,72.5±6.4U/mL at basehne and 74.1 ± 5.1,75.8 ± 6.8U/mL at post - exercise in the CAD and non - CAD groups, p = 0.28 and 0.55, respectively）. The changes in IMA after exercise did not differ either 5.4 ±3.544.7 ±7.6U/mL in the CAD and non - CAD groups, respectively, p = 0.10）. Similarly, the change in IMA between the exercise EGG test positive （TMT positive, n = 16） and negative （TMT negative, n = 33） groups did not differ （6.6± 3.1 U/mL,7.50± 4.2 U/mL, p = 0.15, in the TMT positive and negative groups, respectively）. Conclusions Our results suggest that IMA has limitation in detecting myocardial ischemia during symptom - limited exercise stress tests.
出处
《医学检验与临床》
2012年第2期13-15,共3页
Medical Laboratory Science and Clinics
