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脑缺血小鼠脑组织活化小胶质细胞数量与GDNF及TNF-α含量的相关性 被引量：5

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摘要 目的研究小胶质细胞与GDNF及TNF-α的相关性。方法大脑中动脉栓塞法制做脑梗死模型,PJ34抑制脑梗死小鼠脑内小胶质细胞的活化,免疫组织化学方法检测不同时间活化的小胶质细胞、胶质细胞来源的生长因子(GDNF)及肿瘤坏死因子(TNF-α)的表达。结果随着活化小胶质细胞数量的增加,GDNF也明显增加(r=0.73,P<0.01)而TNF-α则明显减少(r=-0.15,P=0.04)。结论活化的小胶质细胞与GDNF的表达呈正相关,而与TNF-α呈负相关。
作者 王建平 杨直堂 刘聪 许栋乾
机构地区 郑州大学第五附属医院神经内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第11期2334-2335,共2页 Chinese Journal of Gerontology
关键词 小胶质细胞 脑梗死 炎症因子 神经生长因子
分类号 R74 [医药卫生—神经病学与精神病学]
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参考文献12

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二级参考文献10

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中国老年学杂志
2012年 第11期

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