摘要
目的 :探讨巴曲抗栓酶对大鼠肠系膜微动脉血栓的疗效和作用机制。方法 :SD大鼠 2 4只 ,分成 3组 ,0 .9%氯化钠注射液对照组、巴曲抗栓酶 8BU·kg- 1和 16BU·kg- 12个剂量组 ,每组为 8只。分别采用光化学诱导法制作大鼠肠系膜微动脉血栓 ,经显微电视摄像系统和多媒体计算机图象处理技术相结合 ,对巴曲抗栓酶的疗效进行定量分析。结果 :巴曲抗栓酶 8BU·kg- 1组再通率为 38%(3/ 8) ,平均再通时间为 (2 7±s9)min ;16BU·kg- 1组再通率为 50 % (4 / 8) ,平均再通时间为 (34± 2 1)min。结论
AIM: To evaluate the effect and the mechanism of batroxobin in treatng micro artery thrombosis of rat mesentery. METHODS: Twenty four rats were overagely divided into three groups i.e. 0.9% sodium chloride injection, 8 BU·kg -1 of batroxobin and 16 BU·kg -1 of batroxobin, micro artery thrombus formation model was gotten up by the filtered light irradiation and intravascular fluorescein sodium administration. The incidence rate、duration and extent of recanalization in different dosage groups and control group were measured using computer image subtraction. RESULTS: The rates of recanalization were 38% and 50% in 8 BU·kg -1 of batroxbin and 16 BU·kg -1 of batroxobin group, respectively. The mean time of recanlization was 27±9 min in 8 BU·kg -1 of batroxobin group and 34±21 min in 16 BU·kg -1 of batroxobin group, respectively. CONCLUSION: Batroxobin shows a good curative effect on micro artery thrombus of rat mesentery.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2000年第3期202-204,共3页
Chinese Journal of New Drugs and Clinical Remedies
