摘要
目的观察脑缺血后再灌流对脑梗塞灶的影响。方法用氯化三苯四氮唑（ＴＴＣ）染色技术结合电子计算机图像分析系统定量测定肾血管性高血压大鼠（ＲＨＲ）和ＳＤ大鼠（ＳＤＲ）局部脑缺血及脑缺血后再灌流梗塞灶体积。结果发现持续缺血组及缺血后再灌流组ＲＨＲ的梗塞体积分别为２１８．７３±３１．１２ｍｍ３和２０１．２９±３３．７１ｍｍ３而ＳＤＲ持续缺血组及缺血后再灌流组分别为１３１．６１±２０．８８ｍｍ３和１１９．４０±２７．１４ｍｍ３，ＲＨＲ和ＳＤＲ梗塞体积均存在显著差异。结论长期慢性高血压引起的脑侧支循环障碍对脑缺血及缺血后再灌流梗塞灶有重要影响。
Aim To investigate the influence of hypertension on cerebral infarction. Methods Using tribenzol tetranitrozolium chloride(TTC) staining method in combination with computerized image analysis system, we measured the infarct size in renovascular hypertension rats(RHR) and Sprague Dawley rats(SDR). Results After permenant ischemia or reperfusion following ischemia,the infarction size in RHR were 21873±3112 mm3 and 20129±3371 mm3, respectvely; while infarct size in SDR were 13161±2088 mm3 and 11940±2714 mm3, respectively. There are significant difference in experimental infarct sizes between RHR and SDR. The cerebral infarction in RHR is vulnerable to be hemorrhage after reperfusion (n=6). It is thus suggested that the collateral circulation alteration resulted from chronic hypertension has a great influence on infarct size after ischemia and reperfusion.
出处
《高血压杂志》
CSCD
1998年第1期16-19,共4页
Chinese Journal of Hypertension
基金
"八五"医学科技攻关项目资助
关键词
脑缺血
再灌流
慢性
高血压
病理
cerebral ischemia
reperfusion
chronic hypertension
