摘要
目的 探讨真胰岛素 (trueinsulin ,TI)测定在分析 2型糖尿病胰岛 β细胞功能中的意义。 方法 采用双位点夹心放大酶联免疫分析法 (BA -ELISA)及放射免疫分析法 (RIA)对 43例NGT、2 0例IGT及 47例 2型DM患者进行血清TI等的测定 ,初步分析其胰岛β细胞功能。 结果 肥胖的 2型DM及IGT患者血清空腹TI水平不高 (P >0 0 5 ) ,而免疫反应性胰岛素(IRI)则明显升高 (P <0 0 1) ,OGTT 30min及 6 0minTI水平明显低于NGT组 (P <0 0 1)。结论 2型DM患者的高胰岛素血症可能是高胰岛素原血症 ;TI测定较IRI更能确切地评价 β细胞功能及胰岛素敏感性。
Objective To study the value of true insulin (TI) determination in evaluating β-cell function. Methods The levels of TI were determined by new BA-ELISA in 43 NGT,20 IGT and 47 type 2DM subjects,and the β-cell function were evaluated. Results The data showed that the fasting TI levels were no significant difference( P >0 05)among NGT,IGT and type 2 DM groups,but the immunoreactive insulin (IRI) was significantly increased in type 2 DM patients compared to NGT( P <0 01). Conclusion The hyperinsulinemia measured by RIA in type 2 DM could be in part due to hyperproinsulinemia.The determination of TI may have a greater accuracy than that of IRI in evaluating β-cell function. [WT5”HZ]
出处
《山西医科大学学报》
CAS
2000年第2期125-126,共2页
Journal of Shanxi Medical University
关键词
糖尿病
非胰岛素依赖型
胰岛素
Β细胞功能
diabetes mellitus,non-insulin-dependent
insulin
islets of Langerhans
