摘要
目的 探讨原发性肝癌（ＰＬＣ）患者血清磷脂酶Ａ２活性的变化及临床意义。方法 采用［＾３Ｈ］－油酸标记生物膜法检测了６０例ＰＬＣ患者（其中Ⅰ、Ⅱ、Ⅲ期肝癌患者分别为１４例、２３例、２３例）以及１６例手术切除肿瘤后和１９例肝动脉栓塞化疗后患者血清ＰＬＡ２的动态变化。结果 ＰＬＣ患者血清ＰＬＡ２活性２９．２７±４．１５（％）明显高于对照组８．４２±２．０１（％）；
ObjectiveTo Study the change of serum Phospholipase A_2 activity and its clinical significance in patient with primary liver cancer. Methods: PLA_2 activity was determined in 60 patients with PLC and in 35 cases of them after hepatectomy or prechemtherapy by [H] - oletate ra- dioactivity. Results:PLA_2 activity in stage Ⅰ, Ⅱ, Ⅲ patients with PLC was significantly higher than that in control group(P <0. 05), the in- crease of PLA_2 activity was related with the clincal stage and the 1 - year survial rate PLA_2 activity decreased significantly after treatment by hepate- ctomy or prechemotherapy (P <0. 05). Conclusion: It is suggested that the level of PLA_2 activity may be considered as one of the serologic pa- rameter in diagnosis and classification of clinical stage of PLC, therefore,the activity of PLA_2 in serum of PLC Patients may be helpful for estimating the development of disease,the volume of the tumor, the curative affect and prognosis of the patients with PLC.
出处
《重庆医学》
CAS
CSCD
2000年第3期203-204,共2页
Chongqing medicine
