摘要
目的评价妈富隆联合二甲双胍在治疗多囊卵巢综合征的有效性。方法电子检索国内外常用医药学数据库,收集妈富隆联合二甲双胍治疗多囊卵巢综合征的临床研究证据,采用循证医学方法进行文献分析。结果检索到符合纳入标准的妈富隆联合二甲双胍治疗多囊卵巢综合征的文献有9篇,所有研究均表明联合用药能更好地改善激素水平或者促进排卵和妊娠率。结论现有研究显示,妈富隆联合二甲双胍治疗多囊卵巢综合征比单独用药效果好,但是临床随机对照试验质量有待提高,还需更多高质量的临床研究进一步证实其合理性和安全性。
OBJECTIVE To evaluate the efficacy of Marvelon combined with mefformin in the treatment of polycystic ovary syndrome （PCOS）. METHODS Both prospective and retrospective clinical studies on the efficacy of Marvelon combined with mefformin were searched in several databases of medicine and pharmacy, and the data was analyzed by evidence-based literature analysis method. RESULTS There were nine randomized controlled trials （RCTs） in Chinese on Marvelon combined with mefformin for the treatment of PCOS. Marvelon combined with metformin could improve hormone levels, promote ovulation and pregnancy rate markedly. CON- CLUSION It has been demonstrated in the researches that Marvelon combined with metformin is more effective for polycystic ovary syndrome （PCOS） , however, further randomized, double-blind studies with larger sample size are needed to prove the efficacy and safety of Marvelon combined with mefformin.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2012年第11期863-867,共5页
Chinese Pharmaceutical Journal
