摘要
目的观察曲美他嗪对高血压合并无症性心肌缺血(SMI)患者左心室重量、功能特征的影响。方法选择80例SMI患者应用多谱勒超声检测心脏左室结构及功能,根据有无高血压分为对照组、高血压无症状性心肌缺血(HSMI)组,对比两组左室结构、功能异同,并给予曲美他嗪治疗,观察其对左室重构及功能的影响。结果与对照组比较,HSMI组的左室后壁厚度、室间隔厚度、左室重量显著增大,舒张早期与舒张晚期峰值流速的比值(E/A)显著减小,差异有显著性(P<0.01)。治疗后HMSI组左室重量、E/A与治疗前比较差异亦有显著性(P<0.01)。结论高血压合并SMI患者多有左室结构和功能的损害,曲美他嗪可减缓、逆转左室肥厚,从而改善心脏功能。
Objective To observe effects of Trimetazidine of left ventricular remodeling in the patient of silent myocardial ischemia（SMI） with hypertension.Methods Left ventricular remodeling was detected with Doppler ultrasonic examination.Eighty cases of SMI were divided into control group（without hypertension）（n=40） and hypertension SMI（HSMI） group（n=40） and left ventricular remodeling were compared between groups.Effects of Trimetazidine on left ventricular remodeling in the HSMI group were investigated.Results Compared with the control group,thickness of the left ventricular posterior wall,thickness of the interventricular septum and left ventricular weight significantly increased,and E/A value significantly decreased（P0.01） in the HSMI group,There were significant differences in left ventricular weight and E/A in the HSMI group（P0.01）before and after treatment.Conclusion Most HSMI patients have changes of left ventricular structures and functions,and Trimetazidine can alleviate and reverse left ventricular remodeling so as to improve function of the heart.
出处
《中国医药指南》
2012年第12期56-58,共3页
Guide of China Medicine
关键词
曲美他嗪
高血压
无症状性心肌缺血
左心室重构
Trimetazidine
Hypertension
Silent myocardial ischemia
Left Ventricular remodeling
