摘要
目的探讨2型糖尿病肾病患者血清同型半胱氨酸(Hcy)、白介素-6(IL-6)和超敏C-反应蛋白(hs-CRP)水平的变化及其临床意义。方法选择2型糖尿病患者100例,根据尿白蛋白排泄率(UAER)分组,其中无白蛋白尿组(DM组)28例,早期糖尿病肾病组(DN1组)34例,临床糖尿病肾病组(DN2组)38例,另选健康体检者30例作为对照组。采用ELISA法分别测定各组血清Hcy、IL-6水平,应用免疫比浊法测定血清hs-CRP水平。结果 2型糖尿病肾病患者组血清中Hcy IL-6及hs-CRP水平高于正常人组及DM组,且随糖尿病肾病的加重而增高,组间比较差异有显著性(P<0.05)。结论 Hcy IL-6及hs-CRP是2型糖尿病肾病的病理生理过程中重要的炎性介质,在2型糖尿病肾病的发生及发展过程中可能起重要作用。检测Hcy IL-6及hs-CRP有助于DN患者病情及预后的判断。
Objective To investigate the changes of serum Hcy IL-6 and hs-CRP levels in patients diabetic nephritis and the clinical significance.Methods 100 patients with type 2 diabetes were selected for this study.The patients were divided into three groups according to urinary albumin excretion rate（UAER）： 28 patients with normal UAER were DM group.34 patients with microalbuminuria and 38 patients with clinical protein.30 healthy subjects were used as control group.The serum levels of Hcy、IL-6 were measured with was measured enzyme linked immunosorbent assay.The serum levels of hs-CRP level was detected by immunoturbidimetry.Results Serum levels of Hcy IL-6 and hs-CRP were significantly higher in patients with diabetic nephropathy than those in controls（P0.05）.Conclusion Hcy IL-6 and hs-CRP participated in the pathogenesis of diabetic nephropathy.Monitoring the changes of their serum levels was helpful for the management of the disease.and probably be a prognostic factor of DN.
出处
《中国医药指南》
2012年第12期22-23,共2页
Guide of China Medicine
