摘要
目的探讨直肠癌同时性肝转移患者与临床病理因素间关系。方法收集安徽医科大学第一附属医院2006年1月1日～2009年12月31日直肠癌患者359例。回顾性分析直肠癌肝转移患者与临床病理因素关系。选择性别、年龄、血清CEA水平、血清CA19-9水平、病程、大体类型、组织类型、肠壁侵袭深度、病理淋巴结转移和肿瘤大小等10个可能影响肝转移的因素,单因素用χ2检验及t检验,多因素用Logistic回归(SPSS17.0统计软件)进行分析。结果单因素分析显示,年龄(P=0.037)、血清CEA水平(P=0.000)、肠壁侵袭深度(P=0.022)、病理淋巴结转移(P=0.000)与直肠癌同时性肝转移有关。多因素分析显示仅血清CEA水平及病理淋巴结转移与肝转移相关,无论是单因素、还是多因素回归分析,性别、血清CA19-9水平、大体类型、组织类型、肿瘤大小均与肝转移无关。结论血清CEA水平及病理淋巴结转移是直肠癌伴同时性肝转移的2个显著性危险因素。性别、血清CA19-9水平、病程、大体类型、组织类型及肿瘤大小与肝转移无关。
Objective To analyze clinicopathological factors for liver metastasis of rectal cancer.Methods Three hundred and fifty-nine patients with rectal cancer treated from January 1,2006 to December 31,2009 in The First Affiliated Hospital of Anhui Medical University were collected to set up the excel database.Three hundred and twenty-seven patients had no liver metastasis,while thirty-two patients had.Retrospective analysis was made of relationship between patients with rectal cancer liver metastasis with clinicopathologic factors.Ten factors that may affect the liver metastasis were selected,including sex,age,the level of serum CEA,level of serum CA19-9,disease course,gross tumor type,histological type,depth of invasion,pathological lymph node metastasis,and tumor size.We used the Student t test,χ2test for single factor analysis.Multifactor analysis and then correlation analysis were used to evaluate the factors by Logistic Regression（SPSS17.0 for windows）.Results Single factor analysis showed that age（P=0.037）,level of serum CEA（P=0.000）,depth of invasion（P=0.022）,pathological lymph node metastasis（P=0.000）were related with liver metastasis.Multiple factor analysis showed that only serum CEA and pathologic lymph node metastasis were related to the liver metastasis.Both single factor and multi-factor regression analysi showed that sex,level of serum CA19-9,gross tumor type,histological type,tumor size were not related with liver metastasis.Conclusions The level of serum CEA and pathologic lymph node metastasis are independent risk factors for the liver metastasis of rectal cancer.Sex,level of serum CA19-9,disease course,gross type,histological type and tumor size have nothing to do with liver metastasis.
出处
《安徽医药》
CAS
2012年第3期324-326,共3页
Anhui Medical and Pharmaceutical Journal
关键词
直肠癌
肝转移
危险因素
rectal cancer
liver metastasis
factor analysis
