摘要
目的观察盐酸丙帕他莫用于功能性鼻内镜手术患者术后镇痛效果和安全性。方法60例ASAI或Ⅱ级择期在全麻下行鼻内镜鼻窦手术患者，随机分为两组：丙帕他莫组（P组）和对照组（C组），每组30例。P组于手术结束前15min静脉滴注盐酸丙帕他莫2g，C组未用任何镇痛药。持续监测两组血流动力学，记录手术结束时（T1）、拔管前10min（12）、拔管时（T3）、拔管后10min（T4）的心率（HR）和平均动脉压（MAP）变化；对两组患者术后2、4、8、12、24h各时间点进行VAS镇痛评分和BCS舒适度评级；记录术后24h内出现的不良反应。结果P组1、2、13、T4时点的MAP、HR明显低于C组（P〈0．05），与T1时点相比，C组12、耶、T4时点MAP、HR明显升高（P〈0．05）；P组在术后2、4、6h各时点的VAS和BCS评分明显低于C组（P〈0．05）；不良反应P组术后24h内寒战的发生率明显低于C组，差异有显著性（P〈0．05）。结论功能性鼻内镜手术术毕前静脉滴注盐酸丙帕他莫2g，能有效镇痛且能提高术后舒适度，不良反应少，安全可靠。
Objective To investigate the effect and safety of propacetamol in endoscopic nasal surgery patients for postoperative analgesia. Methods Sixty patients undergoing elective endoscopic nasal surgery were randomly di-vided into two groups（30 case in each group） ：propacetamol postoperative analgesia group（ group P）and control group （group C）. Patients of group P were slowly given 2g propacetamol 15mins before operation, and patients of group C with no reatment. VAS scores and BCS scores were observed at 2,4,6,12 and 24 h after operation. HR and MAP of the patients were recorded at T1 ,T2 ,T3 and T4. The adverse reactions were also recorded after operation. Results ：For the HR and MAP,group P were significantly lower than in the group C at T2,T3 and T4（ P 〈0.05）. The VAS scores and BCS scores of group P were significantly lower than that in group C. For the incidence of shivering, group C was remarkably higher than groups P in 24 hours after operation （ P 〈 0.05 ）. Conclusion The analgesic effect of propac-etamol 2g given in vein is effective.safe.and feasible for natients after endoscnnic nasal surgery.
出处
《医学新知》
CAS
2012年第2期119-121,共3页
New Medicine
关键词
盐酸丙帕他莫
鼻内镜手术
术后镇痛
Propacetamol
Endoscopic nasal surgery
Postoperative snalgesia
