摘要
目的观察并比较盐酸丙帕他莫和哌替啶治疗胆绞痛肾绞痛的疗效及安全性。方法将100例急性腹痛患者,按就诊顺序随机分为观察组及对照组,其中74例肾绞痛及26例胆绞痛,两组间性别、年龄、生命体征等差异均无统计学意义。两组按随机、单盲的原则进行治疗。观察组盐酸丙帕他莫2g+0.9%氯化钠100ml于30min内静脉滴注,同时肌肉注射0.9%氯化钠1ml;对照组采用哌替啶50mg肌肉注射,同时0.9%氯化钠100ml于30min内静脉滴注。观察比较给药后1h内两组的镇痛效果及用药后1h的不良反应。结果观察组显效率和总有效率58.0%和92.0%,略低于对照组的60.0%和96.0%,但两组的镇痛效果差异无统计学意义(P>0.05),但不良反应频次比较差异有统计学意义(P<0.01)。结论盐酸丙帕他莫与哌替啶用于治疗胆绞痛肾绞痛镇痛疗效相似,且不良反应少、无成瘾性,值得在临床推广应用。
Objective To compare the efficacy and safety of the propacetamol hydrochloride injection and dulantin in the treatment of acute renal colic and acute biliary colic.Methods 100 patients with acute renal colic or acute biliary colic were randomized into the study against the control group.The study group was treated with 2 g propacetamol in 100 ml normal saline intravenously in 30 min and 1.0 ml normal saline intramuscularly,the control group was treated with 100 ml normal saline intravvenously in 30 min and 50 mg dolantin intramuscularly.The intensity change of renal colic or biliary colic,vital signs and adverse reactions were described during 1h form the beginning of propacetamol infusion.Results The total effective rate of the study group was 92% and that of control group was 96%.The obvious effective rate of the study group was 58% and that of control group was 60%.There was no significant difference between two groups（P0.05）,but the study group had less adverse reactions（P0.01）.Conclusion It showed that Propacetamol HCL and Pethidine HCL had the similar efficacy in treating acute renal colic.Since Propacetamol HCL had less adverse reaction,it would have a future of wide application as analgesic for renal colic and biliary colic.
出处
《中华全科医学》
2010年第11期1369-1370,共2页
Chinese Journal of General Practice
