摘要
利用均四氯乙烷及二氯甲烷的胺化反应,合成了联氢化嘧啶衍生物1～5,4a,8b-反-4,5,8a,9a-四氮杂全氢芴(6)和8b,8c-顺-3a,4a,7a,8a-四氮杂环戊并全氢芴(7)。化合物(6)和(7)的顺反异构体在酸催化下开环,异构生成较稳定的6b和7a。
1,3- diaminoalkanes react with sym - tetrachloroethane to give crystaline 2,2'- Bis - ( hexahydropy-rimidine) derivatives 1 - 5, after treatment with aqua ammonia. Subsequently 1 was treated with different amounts of dichloromethane to give higher yields of 4a, 8b - trans - perhydro - 4, 5, 8a, 9a - tetraazafluorene (6) and 8b, 8c -cis - perhydro- 3a, 4a, 7a, 8a- tetraazacyclopentanofluorene (7) . The transformation mechanisms for cis - and trans - 6 and 7 are proposed.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2000年第2期251-254,共4页
Chinese Journal of Organic Chemistry
基金
内蒙古自然科学基金
关键词
四氯乙烷
胺化反应
联氢化嘧啶
合成
1.3-diaminoalkane, tetrachloroethane, bis-(hexahydropyrimidine)
