摘要
目的电刺激大鼠上矢状窦硬脑膜建立血管源性头痛清醒动物模型,观察经典止痛药物乙酰氨基酚及布洛芬对清醒大鼠的行为学变化,验证此模型的可靠性。方法 30只雄性SD大鼠随机分为对照组(生理盐水组)、对乙酰氨基酚组、布洛芬组,每组给药前及给药后40 min分别给予5 min持续电刺激,观察清醒状态下大鼠用药前后行为学变化,主要观察的行为学指标为甩头次数和过度理毛时间。结果对照组与对乙酰氨基酚组以及对照组与布洛芬组甩头次及理毛时间均减少,差异均具有统计学意义(P<0.05),对乙酰氨基酚组及布洛芬组对模型动物行为学影响的差异无显著统计学意义。结论对乙酰氨基酚和布洛芬明显改善模型动物的头痛症状。清醒状态下大鼠上矢状窦硬脑膜电刺激的头痛模型切实可靠。
Objective To set up a conscious model of vascular headache by electrical stimulation of the superior sagittal sinus and to verify its reliability and feasibility,we observed the behavioral changes of conscious rats which were administrated two classical analgesic drugs that acetaminophen and ibuprofen.Methods 30 male SD rats were randomly divided into three groups：control group（saline group）,acetaminophen group and ibuprofen group.Each group was given electrical stimulation 5 minutes before and 40 minutes after administrated.The number of head-flicks and excessive grooming times were observed as the main parameters.Results There were significant decrease on head-flicks and excessive grooming between the control group and the administration-group（P〈0.05）,while no significant difference between the acetaminophen group and the ibuprofen group.Conclusion Paracetamol and ibuprofen can significantly relieved the symptoms of the headache in this models by administrated.This conscious rat headache models was practical and reliable model.
出处
《中国比较医学杂志》
CAS
2012年第5期1-4,共4页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金项目(30570264
30970417)
