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趋化因子CXCL12及其受体CXCR4与造釉型颅咽管瘤侵袭、复发的相关性研究 被引量：5

Research on the correlativity of expressions of CXCL12 and CXCR4 with the invasiveness and recurrence of adamantimous craniopharyngiomas
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摘要 目的探讨趋化因子及其受体(CXCL12/CXCR4)在造釉细胞型颅咽管瘤中的表达并分析其与肿瘤侵袭、复发的相关性。方法应用免疫组化法和western blot方法对20例造釉细胞型颅咽管瘤标本(原发组11例,复发组9例)中CXCL12/CXCR4的表达进行检测。结果 CXCL12/CXCR4在复发组造釉细胞型颅咽管瘤中的阳性表达明显高于原发组(P<0.05)。结论 CXCL12/CXCR4可能在造釉细胞型颅咽管瘤侵袭、复发过程中起重要的作用。CXCL12/CXCR4可能成为评价造釉细胞型颅咽管瘤侵袭性生长和复发的标记物。 Objective To investigate the correlativity of the expressions of CXCL12 and CXCR4 with the invasiveness and recurrence of adamantimous craniopharyngiomas. Methods The expressions of CXCL12 and CXCR4 were determined by immunohistochemical technique and western blot in 20 cases of adamantimous craniopharyngiomas including 11 cases of the primary tumors and 9 cases of the recurrent tumors. Results The levels of CXCL12 and CXCR4 expressions in the recurrent tumors was significantly higher than those in the primary tumors （P〈0.05）. Conclusion CXCL12 and CXCR4 which may play an important role in the invasion and recurrence of adamantimous craniopharyngiomas may be the potential specific bio-marker related to the invasiveness and recurrence of adamantimous craniopharyngiomas.
作者 刘文庆 宫剑 甲戈 夏志强 赵育梅 王凤梅 孙涛 田继辉
机构地区 宁夏医科大学附属医院神经外科 首都医科大学附属北京天坛医院神经外科
出处 《中国临床神经外科杂志》 2012年第5期289-292,共4页 Chinese Journal of Clinical Neurosurgery
基金 国家自然科学基金(81072074) 北京市教委科技计划重点项目(KZ201110025033) 宁夏回族自治区自然科学基金(NZ09116)资助
关键词 造釉细胞型颅咽管瘤 趋化因子12 趋化因子受体4 侵袭性 复发 Adamantinomatous craniopharyngioma CXCL12 CXCR4 Invasiveness Recurrence
分类号 R739.41 [医药卫生—肿瘤] Q786 [生物学—分子生物学]
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参考文献17

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共引文献33

同被引文献32

  • 1张文敏,黄纲雄,黄爱民,高凌云,高美钦,陈碧芬.uPA和PAI-1在人脑胶质瘤的表达及其与肿瘤血管生成的关系[J].解剖学研究,2005,27(1):15-18. 被引量：2
  • 2王月玲,杨新园,李旭.印记基因H19和胰岛素样生长因子Ⅱ在人子宫颈癌组织中印记缺失及意义[J].西安交通大学学报（医学版）,2006,27(4):372-376. 被引量：6
  • 3蒋玉萍,吴小华.趋化因子CXCL12及其受体与肿瘤转移的关系[J].癌症,2007,26(2):220-224. 被引量：22
  • 4郑安锡,肖文峰,霍钢.侵袭性垂体腺瘤血管生成研究进展[J].现代医学,2007,35(4):332-335. 被引量：3
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引证文献5

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中国临床神经外科杂志
2012年 第5期

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