摘要
卵巢癌干细胞在卵巢癌发生、化疗耐药和复发过程中起重要作用。传统治疗对减小肿瘤体积有效,但是治疗后留下的卵巢癌干细胞成为卵巢癌复发和难治的根源。兼顾卵巢癌干细胞和普通肿瘤细胞的治疗策略才能真正有效治疗卵巢癌。对卵巢癌干细胞生物学特性和调控机制的了解是研究卵巢癌干细胞靶向治疗的基础。
Cancer stem cells or tumor-initiating cells （CSC/TICs） play critical roles in tumorigenesis, traditional therapy resistance, tumor recurrence andmetastasis. Major causes of poor survival rates of o- varian cancer patients are tumor recurrence and che- moresistance due to the existence of CSC/TICs. Treatment targeting both CSC/TICs and bulk tumor cells is thought to be more effective to eliminate ovar- ian tumors. Better understanding of ovarian CSC! TICs might facilitate the development of improved therapeutic strategies for ovarian cancer.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2014年第1期14-17,共4页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
卵巢癌
肿瘤干细胞
ovarian cancer
cancer stem cells
